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Pfizer's Resilience in a Challenging Quarter

November 4, 2025

Highlights

  • Revenue: $16.7B (-7% YoY)
  • Non-COVID product growth: +4% operationally
  • Adjusted diluted EPS: $0.87 (ahead of expectations)
  • Eliquis, Vyndaqel, Nurtec: significant contributors
  • Global operational growth in Prevnar family: +17% YoY
  • Adjusted gross margin: approximately 76%
  • COVID product decline: negatively impacted by reduced demand
  • Operating expense increase: +21% operationally

Pfizer's third-quarter earnings release indicates a nuanced performance amidst shifting market dynamics. While the company faced a 7% decline in overall revenues to $16.7 billion, primarily attributed to decreased demand for COVID-19 products such as Paxlovid and Comirnaty, the strength of its broader portfolio provided a robust counterbalance.

Solid Growth Outside COVID-19

Pfizer's non-COVID products demonstrated resilience, achieving a 4% operational growth amidst the broader revenue decline. Key contributors like Eliquis, the Vyndaqel family, and Nurtec featured prominently, underscoring Pfizer's effective focus on high-priority areas and its strategic strength in diversified revenues beyond pandemic-related products.

Strong Product Performance

Among the standouts, the Vyndaqel family reported a 7% year-over-year global operational growth. Similarly, the Prevnar vaccines showcased significant international success, witnessing a 17% growth in operational performance this quarter. These products underscore Pfizer's continued leadership and strategic positioning in key therapeutic areas, bolstered by its sustained diagnostic and access-driven initiatives.

Financial and Operational Efficiency

The company's sound Q3 financial performance was underscored by an impressive adjusted gross margin of approximately 76% and an increase in third-quarter adjusted diluted EPS to $0.87, outpacing expectations. This reflects Pfizer's disciplined approach to cost management and operational efficiencies, even as adjusted operating expenses rose by 21% due mainly to investments like the 3SBio transaction.

In summary, while Pfizer navigated expected declines in COVID-19-related revenues, the firm continues to demonstrate robustness through strategic product performance and sound financial management, reflecting its ability to sustain growth and operational excellence in diverse areas of its business.